In this Interactive Storytelling (IS) work, we provide a framework for automating several aspects of staging the activities of a population of narrative agents and their interactions. Narrative agents can have differing levels of narrative relevance within the situated narrative actions which are visualised within a 3D real-time virtual world. The solution we propose here offers a framework for integrating the use of multiple dynamic regions within the 3D story world defined through a semantic representation that is able to support the staging of narrative actions through the behaviours of the primary and background agents’ involved. This includes both the mechanics of dealing with the narrative discourse level as well as the interaction with the narrative generation layer to account for any dynamic modifications of the 3D story world. We refer to this approach as MISE -en-scène R egion support ( MISER ) and are providing here details of the demonstration application which users will be able to interact with.